2AF6

Crystal structure of Mycobacterium tuberculosis Flavin dependent thymidylate synthase (Mtb ThyX) in the presence of co-factor FAD and substrate analog 5-Bromo-2'-Deoxyuridine-5'-Monophosphate (BrdUMP)

Summary for 2AF6

Entry DOI	10.2210/pdb2af6/pdb
Descriptor	Thymidylate synthase thyX, IODIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (6 entities in total)
Functional Keywords	m.tuberculosis, thyx, fdts, tscp, flavin dependent thymidylate synthase, transferase
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	8
Total formula weight	243699.20
Authors	Sampathkumar, P.,Turley, S.,Ulmer, J.E.,Rhie, H.G.,Sibley, C.H.,Hol, W.G. (deposition date: 2005-07-25, release date: 2005-10-04, Last modification date: 2023-11-15)
Primary citation	Sampathkumar, P.,Turley, S.,Ulmer, J.E.,Rhie, H.G.,Sibley, C.H.,Hol, W.G. Structure of the Mycobacterium tuberculosis Flavin Dependent Thymidylate Synthase (MtbThyX) at 2.0A Resolution. J.Mol.Biol., 352:1091-1104, 2005 Cited by PubMed: 16139296 DOI: 10.1016/j.jmb.2005.07.071 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.01 Å)

Structure validation