1ZZL

Crystal structure of P38 with triazolopyridine

Summary for 1ZZL

Entry DOI	10.2210/pdb1zzl/pdb
Descriptor	Mitogen-activated protein kinase 14, 6-[4-(4-FLUOROPHENYL)-1,3-OXAZOL-5-YL]-3-ISOPROPYL[1,2,4]TRIAZOLO[4,3-A]PYRIDINE (3 entities in total)
Functional Keywords	phosphorylation, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm (By similarity): Q16539
Total number of polymer chains	1
Total formula weight	40585.38
Authors	McClure, K.F.,Han, S. (deposition date: 2005-06-14, release date: 2005-09-13, Last modification date: 2024-02-14)
Primary citation	McClure, K.F.,Abramov, Y.A.,Laird, E.R.,Barberia, J.T.,Cai, W.,Carty, T.J.,Cortina, S.R.,Danley, D.E.,Dipesa, A.J.,Donahue, K.M.,Dombroski, M.A.,Elliott, N.C.,Gabel, C.A.,Han, S.,Hynes, T.R.,Lemotte, P.K.,Mansour, M.N.,Marr, E.S.,Letavic, M.A.,Pandit, J.,Ripin, D.B.,Sweeney, F.J.,Tan, D.,Tao, Y. Theoretical and Experimental Design of Atypical Kinase Inhibitors: Application to p38 MAP Kinase. J.Med.Chem., 48:5728-5737, 2005 Cited by PubMed: 16134941 DOI: 10.1021/jm050346q PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation