1ZVX

Crystal structure of the complex between MMP-8 and a phosphonate inhibitor (R-enantiomer)

Summary for 1ZVX

Entry DOI	10.2210/pdb1zvx/pdb
Related	1ZS0
Descriptor	Neutrophil collagenase, CALCIUM ION, ZINC ION, ... (5 entities in total)
Functional Keywords	stereoselective inhibition, phosphonic inhibitors, hydrolase, sulfonamide junction
Biological source	Homo sapiens (human)
Cellular location	Cytoplasmic granule: P22894
Total number of polymer chains	1
Total formula weight	18722.12
Authors	Pochetti, G.,Gavuzzo, E.,Campestre, C.,Agamennone, M.,Tortorella, P.,Consalvi, V.,Gallina, C.,Hiller, O.,Tschesche, H.,Tucker, P.A.,Mazza, F. (deposition date: 2005-06-03, release date: 2006-05-16, Last modification date: 2023-08-23)
Primary citation	Pochetti, G.,Gavuzzo, E.,Campestre, C.,Agamennone, M.,Tortorella, P.,Consalvi, V.,Gallina, C.,Hiller, O.,Tschesche, H.,Tucker, P.A.,Mazza, F. Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates. J.Med.Chem., 49:923-931, 2006 Cited by PubMed: 16451058 DOI: 10.1021/jm050787+ PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.87 Å)

Structure validation