1ZUA

Crystal Structure Of AKR1B10 Complexed With NADP+ And Tolrestat

Summary for 1ZUA

Entry DOI	10.2210/pdb1zua/pdb
Related	1ADS 1AH3 1C9W
Descriptor	Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TOLRESTAT, ... (4 entities in total)
Functional Keywords	alpha-beta barrel, aldo-keto reductase, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm (Probable): O60218
Total number of polymer chains	1
Total formula weight	37310.44
Authors	Gallego, O.,Ruiz, F.X.,Ardevol, A.,Dominguez, M.,Alvarez, R.,de Lera, A.R.,Rovira, C.,Farres, J.,Fita, I.,Pares, X. (deposition date: 2005-05-30, release date: 2006-11-07, Last modification date: 2023-10-25)
Primary citation	Gallego, O.,Ruiz, F.X.,Ardevol, A.,Dominguez, M.,Alvarez, R.,de Lera, A.R.,Rovira, C.,Farres, J.,Fita, I.,Pares, X. Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10. Proc.Natl.Acad.Sci.USA, 104:20764-20769, 2007 Cited by PubMed: 18087047 DOI: 10.1073/pnas.0705659105 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.25 Å)

Structure validation