1ZSF

Crystal Structure of Complex of a Hydroxyethylamine Inhibitor with HIV-1 Protease at 2.0A Resolution

Summary for 1ZSF

Entry DOI	10.2210/pdb1zsf/pdb
Related	1FQX 1IIQ 1LZQ 1M0B 1Z8C 1ZBG 1ZJ7 1ZLF 1ZPK 1ZSR
Related PRD ID	PRD_000385
Descriptor	PROTEASE RETROPEPSIN, N-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}-L-phenylalanyl-L-alpha-glutamyl-L-phenylalaninamide (3 entities in total)
Functional Keywords	hiv, protease, peptidomimetic inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 1
Cellular location	Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
Total number of polymer chains	2
Total formula weight	22343.34
Authors	Duskova, J.,Skalova, T.,Dohnalek, J.,Petrokova, H.,Hasek, J. (deposition date: 2005-05-24, release date: 2006-04-25, Last modification date: 2023-11-15)
Primary citation	Duskova, J.,Dohnalek, J.,Skalova, T.,Petrokova, H.,Vondrackova, E.,Hradilek, M.,Konvalinka, J.,Soucek, M.,Brynda, J.,Fabry, M.,Sedlacek, J.,Hasek, J. On the role of the R configuration of the reaction-intermediate isostere in HIV-1 protease-inhibitor binding: X-ray structure at 2.0 A resolution. Acta Crystallogr.,Sect.D, 62:489-497, 2006 Cited by PubMed: 16627941 DOI: 10.1107/S0907444906006718 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.98 Å)

Structure validation