1ZSB

CARBONIC ANHYDRASE II MUTANT E117Q, TRANSITION STATE ANALOGUE ACETAZOLAMIDE

Summary for 1ZSB

Entry DOI	10.2210/pdb1zsb/pdb
Descriptor	CARBONIC ANHYDRASE II, ZINC ION, 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, ... (4 entities in total)
Functional Keywords	lyase, oxo-acid, acetylation, zinc, polymorphism, lyase (oxo-acid)
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P00918
Total number of polymer chains	1
Total formula weight	29444.53
Authors	Lesburg, C.A.,Christianson, D.W. (deposition date: 1996-01-09, release date: 1996-07-11, Last modification date: 2024-02-14)
Primary citation	Huang, C.C.,Lesburg, C.A.,Kiefer, L.L.,Fierke, C.A.,Christianson, D.W. Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II. Biochemistry, 35:3439-3446, 1996 Cited by PubMed: 8639494 DOI: 10.1021/bi9526692 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation