1ZEO
Crystal Structure of Human PPAR-gamma Ligand Binding Domain Complexed with an Alpha-Aryloxyphenylacetic Acid Agonist
Summary for 1ZEO
Entry DOI | 10.2210/pdb1zeo/pdb |
Descriptor | Peroxisome proliferator activated receptor gamma, (2S)-(4-ISOPROPYLPHENYL)[(2-METHYL-3-OXO-5,7-DIPROPYL-2,3-DIHYDRO-1,2-BENZISOXAZOL-6-YL)OXY]ACETATE (3 entities in total) |
Functional Keywords | nuclear receptor, ligand binding domain, lbd, alpha helix sandwich, ppar-rxr heterodimer, transcription |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P37231 |
Total number of polymer chains | 2 |
Total formula weight | 63611.81 |
Authors | Shi, G.Q.,Dropinski, J.F.,McKeever, B.M.,Adams, A.D.,MacNaul, K.L.,Elbrecht, A.,Berger, J.P.,Zhou, G.,Doebber, T.W. (deposition date: 2005-04-19, release date: 2006-04-25, Last modification date: 2024-04-03) |
Primary citation | Shi, G.Q.,Dropinski, J.F.,McKeever, B.M.,Xu, S.,Becker, J.W.,Berger, J.P.,MacNaul, K.L.,Elbrecht, A.,Zhou, G.,Doebber, T.W.,Wang, P.,Chao, Y.-S.,Forrest, M.,Heck, J.V.,Moller, D.E.,Jones, B.A. Design and Synthesis of alpha-Aryloxyphenylacetic Acid Derivatives: A Novel Class of PPAR alpha/gamma Dual Agonists with Potent Antihyperglycemic and Lipid Modulating Activity J.Med.Chem., 48:4457-4468, 2005 Cited by PubMed: 15974597DOI: 10.1021/jm0502135 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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