1YXX

Crystal Structure of Kinase Pim1 in complex with (3E)-3-[(4-HYDROXYPHENYL)IMINO]-1H-INDOL-2(3H)-ONE

Summary for 1YXX

Entry DOI	10.2210/pdb1yxx/pdb
Related	1YWV 1YXS 1YXT 1YXU 1YXV
Descriptor	Proto-oncogene serine/threonine-protein kinase Pim-1, IMIDAZOLE, (3E)-3-[(4-HYDROXYPHENYL)IMINO]-1H-INDOL-2(3H)-ONE, ... (4 entities in total)
Functional Keywords	ser/thr protein kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains	1
Total formula weight	34139.65
Authors	Kumar, A.,Mandiyan, V.,Suzuki, Y.,Zhang, C.,Rice, J.,Tsai, J.,Artis, D.R.,Ibrahim, P.,Bremer, R. (deposition date: 2005-02-22, release date: 2005-04-26, Last modification date: 2024-02-14)
Primary citation	Kumar, A.,Mandiyan, V.,Suzuki, Y.,Zhang, C.,Rice, J.,Tsai, J.,Artis, D.R.,Ibrahim, P.,Bremer, R. Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma. J.Mol.Biol., 348:183-193, 2005 Cited by PubMed: 15808862 DOI: 10.1016/j.jmb.2005.02.039 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation