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1YWR

Crystal Structure Analysis of inactive P38 kinase domain in complex with a Monocyclic Pyrazolone Inhibitor

Summary for 1YWR
Entry DOI10.2210/pdb1ywr/pdb
Related1yw2
DescriptorMitogen-activated protein kinase 14, 4-(4-FLUOROPHENYL)-1-METHYL-5-(2-{[(1S)-1-PHENYLETHYL]AMINO}PYRIMIDIN-4-YL)-2-PIPERIDIN-4-YL-1,2-DIHYDRO-3H-PYRAZOL-3-ONE (3 entities in total)
Functional Keywordsp38 kinase, moncyclic pyrazolone, transferase
Biological sourceMus musculus (house mouse)
Cellular locationCytoplasm : P47811
Total number of polymer chains1
Total formula weight41794.72
Authors
Primary citationGolebiowski, A.,Townes, J.A.,Laufersweiler, M.J.,Brugel, T.A.,Clark, M.P.,Clark, C.M.,Djung, J.F.,Laughlin, S.K.,Sabat, M.P.,Bookland, R.G.,Vanrens, J.C.,De, B.,Hsieh, L.C.,Janusz, M.J.,Walter, R.L.,Webster, M.E.,Mekel, M.J.
The development of monocyclic pyrazolone based cytokine synthesis inhibitors.
Bioorg.Med.Chem.Lett., 15:2285-2289, 2005
Cited by
PubMed: 15837310
DOI: 10.1016/j.bmcl.2005.03.007
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.95 Å)
Structure validation

217705

數據於2024-03-27公開中

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