1Y75

A new form of catalytically inactive phospholipase A2 with an unusual disulphide bridge Cys 32- Cys 49 reveals recognition for N-acetylglucosmine

Summary for 1Y75

• Entry DOI: 10.2210/pdb1y75/pdb
• Related: 1S6B
• Descriptor: phospholipase A2 isoform 5, phospholipase A2 isoform 6, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: enzyme, activity, molecular association, hydrolase
• Biological source: Naja sagittifera; More
• Cellular location: Secreted: Q5G291 Q5G290
• Total number of polymer chains: 2
• Total formula weight: 26139.60

Authors

Jabeen, T.,Singh, N.,Jasti, J.,Singh, R.K.,Sharma, S.,Perbandt, M.,Betzel, C.,Kaur, P.,Srinivasan, A.,Singh, T.P. (deposition date: 2004-12-08, release date: 2005-05-03, Last modification date: 2020-07-29)

• Primary citation: Jabeen, T.,Singh, N.,Singh, R.K.,Jasti, J.,Sharma, S.,Kaur, P.,Srinivasan, A.,Singh, T.P.; Crystal structure of a heterodimer of phospholipase A2 from Naja naja sagittifera at 2.3 A resolution reveals the presence of a new PLA2-like protein with a novel cys 32-Cys 49 disulphide bridge with a bound sugar at the substrate-binding site; Proteins, 62:329-337, 2006; PubMed: 16287060; DOI: 10.1002/prot.20708

Experimental method

X-RAY DIFFRACTION (2.3 Å)