1XL0

Kinetic and crystallographic studies on 2-(beta-D-glucopyranosyl)-5-methyl-1,3,4-oxadiazole,-benzothiazole, and-benzimidazole, inhibitors of muscle glycogen phosphorylase b. Evidence for a new binding site.

1XL0 の概要

• エントリーDOI: 10.2210/pdb1xl0/pdb
• 関連するPDBエントリー: 1K06 1P4G 1P4H 1P4J 1XKX 1XL1
• 分子名称: Glycogen phosphorylase, muscle form, (1R)-1,5-anhydro-1-(5-methyl-1,3,4-oxadiazol-2-yl)-D-glucitol, PYRIDOXAL-5'-PHOSPHATE, ... (4 entities in total)
• 機能のキーワード: glycogenolysis, type 2 diabetes, transferase
• 由来する生物種: Oryctolagus cuniculus (rabbit)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 97784.56

構造登録者

Chrysina, E.D.,Kosmopoulou, M.N.,Tiraidis, C.,Kardakaris, R.,Bischler, N.,Leonidas, D.D.,Hadady, Z.,Somsak, L.,Docsa, T.,Gergely, P.,Oikonomakos, N.G. (登録日: 2004-09-30, 公開日: 2005-03-15, 最終更新日: 2020-07-29)

• 主引用文献: Chrysina, E.D.,Kosmopoulou, M.N.,Tiraidis, C.,Kardakaris, R.,Bischler, N.,Leonidas, D.D.,Hadady, Z.,Somsak, L.,Docsa, T.,Gergely, P.,Oikonomakos, N.G.; Kinetic and crystallographic studies on 2-(beta-D-glucopyranosyl)-5-methyl-1, 3, 4-oxadiazole, -benzothiazole, and -benzimidazole, inhibitors of muscle glycogen phosphorylase b. Evidence for a new binding site; Protein Sci., 14:873-888, 2005; PubMed: 15741340; DOI: 10.1110/ps.041216105

実験手法

X-RAY DIFFRACTION (1.92 Å)