1XBO

PTP1B complexed with Isoxazole Carboxylic Acid

1XBO の概要

• エントリーDOI: 10.2210/pdb1xbo/pdb
• 関連するPDBエントリー: 1NL9 1NNY 1NO6 1NZZ 1ONY 1ONZ
• 分子名称: Protein-tyrosine phosphatase, non-receptor type 1, 5-(3-{3-[3-HYDROXY-2-(METHOXYCARBONYL)PHENOXY]PROPENYL}PHENYL)-4-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLIC ACID (3 entities in total)
• 機能のキーワード: protein tyrosine phosphatase 1b, ptp1b, isoxazole carboxylic acid, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37791.03

構造登録者

Zhao, H.,Liu, G.,Xin, Z.,Serby, M.,Pei, Z.,Szczepankiewicz, B.G.,Hajduk, P.J.,Abad-Zapatero, C.,Hutchins, C.W.,Lubben, T.H.,Ballaron, S.J.,Hassach, D.L.,Kaszubska, W.,Rondinone, C.M.,Trevillyan, J.M.,Jirousek, M.R. (登録日: 2004-08-31, 公開日: 2004-10-19, 最終更新日: 2023-08-23)

• 主引用文献: Zhao, H.,Liu, G.,Xin, Z.,Serby, M.D.,Pei, Z.,Szczepankiewicz, B.G.,Hajduk, P.J.,Abad-Zapatero, C.,Hutchins, C.W.,Lubben, T.H.,Ballaron, S.J.,Haasch, D.L.,Kaszubska, W.,Rondinone, C.M.,Trevillyan, J.M.,Jirousek, M.R.; Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors.; Bioorg.Med.Chem.Lett., 14:5543-5546, 2004; PubMed: 15482920; DOI: 10.1016/j.bmcl.2004.08.063

実験手法

X-RAY DIFFRACTION (2.5 Å)