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1X97

Crystal structure of Aldose Reductase complexed with 2R4S (Stereoisomer of Fidarestat, 2S4S)

Summary for 1X97
Entry DOI10.2210/pdb1x97/pdb
Related1PWM 1X96 1X98
DescriptorAldose Reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2R,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE, ... (4 entities in total)
Functional Keywordseight strandard alpha/beta barrel, active site, the c-terminal end of the barrel, oxidoreductase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: P15121
Total number of polymer chains1
Total formula weight36920.97
Authors
El-Kabbani, O.,Darmanin, C.,Oka, M.,Schulze-Briese, C.,Tomizaki, T.,Hazemann, I.,Mitschler, A.,Podjarny, A. (deposition date: 2004-08-19, release date: 2004-09-07, Last modification date: 2023-10-25)
Primary citationEl-Kabbani, O.,Darmanin, C.,Oka, M.,Schulze-Briese, C.,Tomizaki, T.,Hazemann, I.,Mitschler, A.,Podjarny, A.
High-Resolution Structures of Human Aldose Reductase Holoenzyme in Complex with Stereoisomers of the Potent Inhibitor Fidarestat: Stereospecific Interaction between the Enzyme and a Cyclic Imide Type Inhibitor
J.Med.Chem., 47:4530-4537, 2004
Cited by
PubMed: 15317464
DOI: 10.1021/jm0497794
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.4 Å)
Structure validation

217705

數據於2024-03-27公開中

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