1X96

Crystal structure of Aldose Reductase with citrates bound in the active site

Summary for 1X96

Entry DOI	10.2210/pdb1x96/pdb
Related	1PWM 1X97 1X98
Descriptor	aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CITRIC ACID, ... (4 entities in total)
Functional Keywords	eight strandard alpha/beta barrel, active site, the c-terminal end of the barrel, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P15121
Total number of polymer chains	1
Total formula weight	37025.99
Authors	El-Kabbani, O.,Darmanin, C.,Oka, M.,Schulze-Briese, C.,Tomizaki, T.,Hazemann, I.,Mitschler, A.,Podjarny, A. (deposition date: 2004-08-19, release date: 2004-09-07, Last modification date: 2023-10-25)
Primary citation	El-Kabbani, O.,Darmanin, C.,Oka, M.,Schulze-Briese, C.,Tomizaki, T.,Hazemann, I.,Mitschler, A.,Podjarny, A. High-Resolution Structures of Human Aldose Reductase Holoenzyme in Complex with Stereoisomers of the Potent Inhibitor Fidarestat: Stereospecific Interaction between the Enzyme and a Cyclic Imide Type Inhibitor J.Med.Chem., 47:4530-4537, 2004 Cited by PubMed: 15317464 DOI: 10.1021/jm0497794 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation