1X95

Solution structure of the DNA-hexamer ATGCAT complexed with DNA Bis-intercalating Anticancer Drug XR5944 (MLN944)

Summary for 1X95

• Entry DOI: 10.2210/pdb1x95/pdb
• Related: 2MG8
• Descriptor: 5'-D(*AP*TP*GP*CP*AP*T)-3', 1-METHYL-9-[12-(9-METHYLPHENAZIN-10-IUM-1-YL)-12-OXO-2,11-DIAZA-5,8-DIAZONIADODEC-1-ANOYL]PHENAZIN-10-IUM (2 entities in total)
• Functional Keywords: anticancer drug, transcription inhibition, novel dna binding, ap-1, mln944, dna
• Total number of polymer chains: 2
• Total formula weight: 4207.18

Authors

Dai, J.,Punchihewa, C.,Mistry, P.,Ooi, A.T.,Yang, D. (deposition date: 2004-08-19, release date: 2004-09-28, Last modification date: 2014-09-17)

• Primary citation: Dai, J.,Punchihewa, C.,Mistry, P.,Ooi, A.T.,Yang, D.; Novel DNA bis-intercalation by MLN944, a potent clinical bisphenazine anticancer drug.; J.Biol.Chem., 279:46096-46103, 2004; PubMed: 15317822; DOI: 10.1074/jbc.M404053200

Experimental method

SOLUTION NMR