Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

1X81

Farnesyl transferase structure of Jansen compound

Summary for 1X81
Entry DOI10.2210/pdb1x81/pdb
Related1NI1
DescriptorProtein farnesyltransferase/geranylgeranyltransferase type I alpha subunit, Protein farnesyltransferase beta subunit, ZINC ION, ... (4 entities in total)
Functional Keywordsfanesyltransferase, transferase
Biological sourceRattus norvegicus (Norway rat)
More
Total number of polymer chains2
Total formula weight83062.40
Authors
Li, Q.,Claiborne, A.,Li, T.,Hasvold, L.,Stoll, V.S.,Muchmore, S.,Jakob, C.G.,Gu, W.,Cohen, J.,Hutchins, C.,Frost, D.,Rosenberg, S.H.,Sham, H.L. (deposition date: 2004-08-16, release date: 2004-12-21, Last modification date: 2024-02-14)
Primary citationLi, Q.,Claiborne, A.,Li, T.,Hasvold, L.,Stoll, V.S.,Muchmore, S.,Jakob, C.G.,Gu, W.,Cohen, J.,Hutchins, C.,Frost, D.,Rosenberg, S.H.,Sham, H.L.
Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors.
Bioorg.Med.Chem.Lett., 14:5367-5370, 2004
Cited by
PubMed: 15454228
DOI: 10.1016/j.bmcl.2004.08.012
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.5 Å)
Structure validation

217705

数据于2024-03-27公开中

PDB statisticsPDBj update infoContact PDBjnumon