1UUD

NMR structure of a synthetic small molecule, rbt203, bound to HIV-1 TAR RNA

Summary for 1UUD

• Entry DOI: 10.2210/pdb1uud/pdb
• Related: 1UTS 1UUI
• Descriptor: RNA (5'-(*GP*GP*CP*AP*GP*AP*UP*CP*UP*GP*AP*GP *CP*CP*UP*GP*GP*GP*AP*GP*CP*UP*CP*UP*CP*UP*GP*CP*C) -3'), N-[2-(2-{[(4-{[AMINO(IMINO)METHYL]AMINO}BUTYL)AMINO]METHYL}-4-METHOXYPHENOXY)ETHYL]GUANIDINE (2 entities in total)
• Functional Keywords: hiv-1, tar rna, drug design, ligand-rna interaction, rna bulge
• Biological source: HUMAN IMMUNODEFICIENCY VIRUS 1 (CLONE 12) (HIV-1)
• Total number of polymer chains: 1
• Total formula weight: 9661.02

Authors

Davis, B.,Afshar, M.,Varani, G.,Karn, J.,Murchie, A.I.H.,Lentzen, G.,Drysdale, M.J.,Potter, A.J.,Bower, J.,Aboul-Ela, F. (deposition date: 2003-12-18, release date: 2004-03-15, Last modification date: 2011-07-13)

• Primary citation: Davis, B.,Afshar, M.,Varani, G.,Murchie, A.I.H.,Karn, J.,Lentzen, G.,Drysdale, M.J.,Bower, J.,Potter, A.J.,Aboul-Ela, F.; Rational Design of Inhibitors of HIV-1 Tar RNA Through the Stabilisation of Electrostatic "Hot Spots"; J.Mol.Biol., 336:343-, 2004; PubMed: 14757049; DOI: 10.1016/J.JMB.2003.12.046

Experimental method

SOLUTION NMR