1UK2

Crystal structure of SARS Coronavirus Main Proteinase (3CLpro) At pH8.0

Summary for 1UK2

• Entry DOI: 10.2210/pdb1uk2/pdb
• Related: 1UK3 1UK4
• Descriptor: 3C-LIKE PROTEINASE (2 entities in total)
• Functional Keywords: anti-parallel b-barrel, anti-parallel a-helices, hydrolase
• Biological source: SARS coronavirus
• Cellular location: Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity). Helicase: Host endoplasmic reticulum-Golgi intermediate compartment (Potential). Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region (By similarity): P59641
• Total number of polymer chains: 2
• Total formula weight: 67753.27

Authors

Yang, H.,Yang, M.,Liu, Y.,Bartlam, M.,Ding, Y.,Lou, Z.,Sun, L.,Zhou, Z.,Ye, S.,Anand, K.,Pang, H.,Gao, G.F.,Hilgenfeld, R.,Rao, Z. (deposition date: 2003-08-14, release date: 2003-11-18, Last modification date: 2023-12-27)

• Primary citation: Yang, H.,Yang, M.,Ding, Y.,Liu, Y.,Lou, Z.,Zhou, Z.,Sun, L.,Mo, L.,Ye, S.,Pang, H.,Gao, G.F.,Anand, K.,Bartlam, M.,Hilgenfeld, R.,Rao, Z.; The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor; Proc.Natl.Acad.Sci.USA, 100:13190-13195, 2003; PubMed: 14585926; DOI: 10.1073/pnas.1835675100

Experimental method

X-RAY DIFFRACTION (2.2 Å)