1TMJ

Crystal structure of E.coli apo-HPPK(W89A) at 1.45 Angstrom resolution

Summary for 1TMJ

Entry DOI	10.2210/pdb1tmj/pdb
Related	1CBK 1DY3 1EQ0 1EQM 1EX8 1F9H 1F9Y 1G4C 1HKA 1HQ2 1IM6 1KBR 1Q0N 1RB0 1RTZ 1RU1 1RU2 1TMM
Descriptor	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, MAGNESIUM ION, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	pyrophosphokinase, pyrophosphoryl transfer, folate, hppk, 6-hydroxymethylpterin, 6-hydroxymethyl-7, 8-dihydropterin, antimicrobial agent, drug design, point mutant, structural mutagenesis, transferase
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	17935.47
Authors	Blaszczyk, J.,Ji, X. (deposition date: 2004-06-10, release date: 2005-06-21, Last modification date: 2023-08-30)
Primary citation	Li, Y.,Blaszczyk, J.,Wu, Y.,Shi, G.,Ji, X.,Yan, H. Is the Critical Role of Loop 3 of Escherichia coli 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase in Catalysis Due to Loop-3 Residues Arginine-84 and Tryptophan-89? Site-Directed Mutagenesis, Biochemical, and Crystallographic Studies. Biochemistry, 44:8590-8599, 2005 Cited by PubMed: 15952765 DOI: 10.1021/bi0503495 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation