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1TL8

Human DNA topoisomerase I (70 kDa) in complex with the indenoisoquinoline AI-III-52 and covalent complex with a 22 base pair DNA duplex

Summary for 1TL8
Entry DOI10.2210/pdb1tl8/pdb
Related1K4t
Descriptor5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', 5'-D(*(TPC)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*GP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', ... (5 entities in total)
Functional Keywordscomplex (isomerase-dna), dna, topoisomerase i, drug, poison, idenoisoquinoline, isomerase-dna complex, isomerase/dna
Biological sourceHomo sapiens (human)
Cellular locationNucleus, nucleolus: P11387
Total number of polymer chains4
Total formula weight84038.30
Authors
Ioanoviciu, A.,Antony, S.,Pommier, Y.,Staker, B.L.,Stewart, L.,Cushman, M. (deposition date: 2004-06-09, release date: 2005-06-21, Last modification date: 2011-07-13)
Primary citationIoanoviciu, A.,Antony, S.,Pommier, Y.,Staker, B.L.,Stewart, L.,Cushman, M.
Synthesis and Mechanism of Action Studies of a Series of Norindenoisoquinoline Topoisomerase I Poisons Reveal an Inhibitor with a Flipped Orientation in the Ternary DNA-Enzyme-Inhibitor Complex As Determined by X-ray Crystallographic Analysis
J.Med.Chem., 48:4803-4814, 2005
Cited by
PubMed: 16033260
DOI: 10.1021/jm050076b
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.1 Å)
Structure validation

217705

數據於2024-03-27公開中

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