1TL3
Crystal structure of hiv-1 reverse transcriptase in complex with gw450557
Summary for 1TL3
| Entry DOI | 10.2210/pdb1tl3/pdb |
| Descriptor | Pol polyprotein, Reverse transcriptase, Chain A, Pol polyprotein, Reverse transcriptase, Chain B, PHOSPHATE ION, ... (4 entities in total) |
| Functional Keywords | hiv-1 reverse transcriptase, aids, nnrti, gw450557, drug design, transferase |
| Biological source | Human immunodeficiency virus 1 More |
| Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 P04585 |
| Total number of polymer chains | 2 |
| Total formula weight | 116598.74 |
| Authors | Hopkins, A.L.,Ren, J.,Stuart, D.I.,Stammers, D.K. (deposition date: 2004-06-09, release date: 2004-12-07, Last modification date: 2022-12-21) |
| Primary citation | Hopkins, A.L.,Ren, J.,Milton, J.,Hazen, R.J.,Chan, J.H.,Stuart, D.I.,Stammers, D.K. Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1. J.Med.Chem., 47:5912-5922, 2004 Cited by PubMed: 15537346DOI: 10.1021/jm040071z PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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