1THZ

Crystal Structure of Avian AICAR Transformylase in Complex with a Novel Inhibitor Identified by Virtual Ligand Screening

Summary for 1THZ

Entry DOI	10.2210/pdb1thz/pdb
Related	1G8M 1M9N 1OZ0 1P4R 1PKX 1PL0
Descriptor	Bifunctional purine biosynthesis protein PURH, POTASSIUM ION, 2-{(E)-[5-HYDROXY-3-METHYL-1-(2-METHYL-4-SULFOPHENYL)-1H-PYRAZOL-4-YL]DIAZENYL}-4-SULFOBENZOIC ACID, ... (4 entities in total)
Functional Keywords	atic, virtual ligand screening, purine biosynthesis, cancer target, transferase, hydrolase
Biological source	Gallus gallus (chicken)
Total number of polymer chains	2
Total formula weight	130066.54
Authors	Xu, L.,Li, C.,Olson, A.J.,Wilson, I.A. (deposition date: 2004-06-01, release date: 2004-09-07, Last modification date: 2023-08-23)
Primary citation	Xu, L.,Li, C.,Olson, A.J.,Wilson, I.A. Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening. J.Biol.Chem., 279:50555-50565, 2004 Cited by PubMed: 15355974 DOI: 10.1074/jbc.M406801200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation