1THK

Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II

Summary for 1THK

Entry DOI	10.2210/pdb1thk/pdb
Related	1T9N 1TB0 1TBT 1TE3 1TEQ 1TEU 1TG3 1TG9 1TH9
Descriptor	Carbonic anhydrase II, ZINC ION (3 entities in total)
Functional Keywords	proton shuttle carbonic anhydrase metalloenzyme, lyase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	29378.51
Authors	Fisher, Z.,Hernandez Prada, J.A.,Tu, C.K.,Duda, D.,Yoshioka, C.,An, H.,Govindasamy, L.,Silverman, D.N.,McKenna, R. (deposition date: 2004-06-01, release date: 2005-01-25, Last modification date: 2023-08-23)
Primary citation	Fisher, Z.,Hernandez Prada, J.A.,Tu, C.K.,Duda, D.,Yoshioka, C.,An, H.,Govindasamy, L.,Silverman, D.N.,McKenna, R. Structural and Kinetic Characterization of Active-Site Histidine as a Proton Shuttle in Catalysis by Human Carbonic Anhydrase II Biochemistry, 44:1097-1105, 2005 Cited by PubMed: 15667203 DOI: 10.1021/bi0480279 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation