1TCO

TERNARY COMPLEX OF A CALCINEURIN A FRAGMENT, CALCINEURIN B, FKBP12 AND THE IMMUNOSUPPRESSANT DRUG FK506 (TACROLIMUS)

1TCO の概要

• エントリーDOI: 10.2210/pdb1tco/pdb
• 分子名称: SERINE/THREONINE PHOSPHATASE B2, FK506-BINDING PROTEIN, ZINC ION, ... (10 entities in total)
• 機能のキーワード: complex (hydrolase-isomerase), immunosuppressant, complex (hydrolase-isomerase) complex, complex (hydrolase/isomerase)
• 由来する生物種: Bos taurus (cattle); 詳細
• 細胞内の位置: Nucleus (By similarity): P48452; Cytoplasm: P62942
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 75364.00

構造登録者

Griffith, J.P.,Kim, J.L.,Kim, E.E.,Sintchak, M.D.,Thomson, J.A.,Fitzgibbon, M.J.,Fleming, M.A.,Caron, P.R.,Hsiao, K.,Navia, M.A. (登録日: 1996-08-21, 公開日: 1997-02-12, 最終更新日: 2011-07-13)

• 主引用文献: Griffith, J.P.,Kim, J.L.,Kim, E.E.,Sintchak, M.D.,Thomson, J.A.,Fitzgibbon, M.J.,Fleming, M.A.,Caron, P.R.,Hsiao, K.,Navia, M.A.; X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex.; Cell(Cambridge,Mass.), 82:507-522, 1995; PubMed: 7543369; DOI: 10.1016/0092-8674(95)90439-5

実験手法

X-RAY DIFFRACTION (2.5 Å)