1T7D

Crystal structure of Escherichia coli type I signal peptidase in complex with a lipopeptide inhibitor

Summary for 1T7D

Entry DOI	10.2210/pdb1t7d/pdb
Related	1B12 1KN9 3IIQ
Related PRD ID	PRD_000117
Descriptor	SIGNAL PEPTIDASE I, ARYLOMYCIN A2, 10-METHYLUNDECANOIC ACID, ... (4 entities in total)
Functional Keywords	signal peptidase, ser/lys dyad, hydrolase, lipopeptide, antibiotic, biaryl bridge, hydrolase-antibiotic complex, hydrolase/antibiotic
Biological source	ESCHERICHIA COLI More
Cellular location	Cell inner membrane; Multi-pass membrane protein: P00803
Total number of polymer chains	4
Total formula weight	57849.61
Authors	Paetzel, M.,Goodall, J.J.,Kania, M.,Dalbey, R.E.,Page, M.G.P. (deposition date: 2004-05-09, release date: 2004-07-13, Last modification date: 2023-08-23)
Primary citation	Paetzel, M.,Goodall, J.J.,Kania, M.,Dalbey, R.E.,Page, M.G.P. Crystallographic and Biophysical Analysis of a Bacterial Signal Peptidase in Complex with a Lipopeptide Based Inhibitor. J.Biol.Chem., 279:30781-, 2004 Cited by PubMed: 15136583 DOI: 10.1074/JBC.M401686200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.47 Å)

Structure validation