1T46

STRUCTURAL BASIS FOR THE AUTOINHIBITION AND STI-571 INHIBITION OF C-KIT TYROSINE KINASE

Summary for 1T46

Entry DOI	10.2210/pdb1t46/pdb
Related	1PKG 1T45
Descriptor	Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, PHOSPHATE ION, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, ... (4 entities in total)
Functional Keywords	kinase, inhibitor, sti-571, gleevec, transferase activator
Biological source	Homo sapiens (human) More
Total number of polymer chains	1
Total formula weight	36072.48
Authors	Mol, C.D.,Dougan, D.R.,Schneider, T.R.,Skene, R.J.,Kraus, M.L.,Scheibe, D.N.,Snell, G.P.,Zou, H.,Sang, B.C.,Wilson, K.P. (deposition date: 2004-04-28, release date: 2004-06-15, Last modification date: 2024-02-14)
Primary citation	Mol, C.D.,Dougan, D.R.,Schneider, T.R.,Skene, R.J.,Kraus, M.L.,Scheibe, D.N.,Snell, G.P.,Zou, H.,Sang, B.C.,Wilson, K.P. Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase. J.Biol.Chem., 279:31655-31663, 2004 Cited by PubMed: 15123710 DOI: 10.1074/jbc.M403319200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation