1SCN

INACTIVATION OF SUBTILISIN CARLSBERG BY N-(TERT-BUTOXYCARBONYL-ALANYL-PROLYL-PHENYLALANYL)-O-BENZOL HYDROXYLAMINE: FORMATION OF COVALENT ENZYME-INHIBITOR LINKAGE IN THE FORM OF A CARBAMATE DERIVATIVE

Summary for 1SCN

Entry DOI	10.2210/pdb1scn/pdb
Related PRD ID	PRD_000260
Descriptor	SUBTILISIN CARLSBERG, N-(tert-butoxycarbonyl)-L-alanyl-N-[(1R)-1-(carboxyamino)-2-phenylethyl]-L-prolinamide, CALCIUM ION, ... (5 entities in total)
Functional Keywords	hydrolase-hydrolase inhibitor complex, serine proteinase, hydrolase/hydrolase inhibitor
Biological source	Bacillus licheniformis
Cellular location	Secreted: P00780
Total number of polymer chains	1
Total formula weight	28026.05
Authors	Steinmetz, A.C.U.,Demuth, H.-U.,Ringe, D. (deposition date: 1994-03-02, release date: 1994-08-31, Last modification date: 2017-11-29)
Primary citation	Steinmetz, A.C.,Demuth, H.U.,Ringe, D. Inactivation of subtilisin Carlsberg by N-((tert-butoxycarbonyl)alanylprolylphenylalanyl)-O-benzolhydroxyl- amine: formation of a covalent enzyme-inhibitor linkage in the form of a carbamate derivative. Biochemistry, 33:10535-10544, 1994 Cited by PubMed: 8068694 DOI: 10.1021/bi00200a040 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation