1RQJ

Active Conformation of Farnesyl Pyrophosphate Synthase Bound to Isopentyl Pyrophosphate and Risedronate

Summary for 1RQJ

Entry DOI	10.2210/pdb1rqj/pdb
Related	1RQI 1RTR
Descriptor	Geranyltranstransferase, MAGNESIUM ION, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ... (5 entities in total)
Functional Keywords	bisphosphonate, isoprenyl synthase, transferase
Biological source	Escherichia coli
Cellular location	Cytoplasm: P22939
Total number of polymer chains	2
Total formula weight	65599.47
Authors	Hosfield, D.J.,Zhang, Y.,Dougan, D.R.,Brooun, A.,Tari, L.W.,Swanson, R.V.,Finn, J. (deposition date: 2003-12-05, release date: 2004-03-02, Last modification date: 2024-02-14)
Primary citation	Hosfield, D.J.,Zhang, Y.,Dougan, D.R.,Brooun, A.,Tari, L.W.,Swanson, R.V.,Finn, J. Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis J.Biol.Chem., 279:8526-8529, 2004 Cited by PubMed: 14672944 DOI: 10.1074/jbc.C300511200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation