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1RH3

DIHYDROFOLATE REDUCTASE COMPLEXED WITH METHOTREXATE AND NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (REDUCED FORM)

Summary for 1RH3
Entry DOI10.2210/pdb1rh3/pdb
DescriptorDIHYDROFOLATE REDUCTASE, METHOTREXATE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
Functional Keywordsoxidoreductase, nadp, trimethoprim resistance, methotrexate resistance, one-carbon metabolism
Biological sourceEscherichia coli
Total number of polymer chains1
Total formula weight19218.17
Authors
Sawaya, M.R.,Kraut, J. (deposition date: 1996-11-27, release date: 1997-03-12, Last modification date: 2023-08-09)
Primary citationSawaya, M.R.,Kraut, J.
Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence.
Biochemistry, 36:586-603, 1997
Cited by
PubMed: 9012674
DOI: 10.1021/bi962337c
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

217705

數據於2024-03-27公開中

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