1REJ

Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 1

1REJ の概要

• エントリーDOI: 10.2210/pdb1rej/pdb
• 関連するPDBエントリー: 1ATP 1BX6 1RE8
• 分子名称: cAMP-dependent protein kinase, alpha-catalytic subunit, 3-[(4-HYDROXYBENZOYL)AMINO]AZEPAN-4-YL 4-HYDROXYBENZOATE (3 entities in total)
• 機能のキーワード: protein kinase, natural product inhibitor, ligand binding, specificity determinants, conformational malleability, transferase
• 由来する生物種: Mus musculus (house mouse)
• 細胞内の位置: Cytoplasm . Isoform 2: Cell projection, cilium, flagellum : P05132
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41027.71

構造登録者

Akamine, P.,Madhusudan,Brunton, L.L.,Ou, H.D.,Canaves, J.M.,Xuong, N.H.,Taylor, S.S. (登録日: 2003-11-06, 公開日: 2004-02-24, 最終更新日: 2023-08-23)

• 主引用文献: Akamine, P.,Madhusudan,Brunton, L.L.,Ou, H.D.,Canaves, J.M.,Xuong, N.H.,Taylor, S.S.; Balanol analogues probe specificity determinants and the conformational malleability of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase catalytic subunit; Biochemistry, 43:85-96, 2004; PubMed: 14705934

実験手法

X-RAY DIFFRACTION (2.2 Å)