1QXK

Monoacid-Based, Cell Permeable, Selective Inhibitors of Protein Tyrosine Phosphatase 1B

1QXK の概要

関連するPDBエントリー1NL9 1NNY 1NO6 1NZ7 1ONY 1PHO
分子名称Protein-tyrosine phosphatase, non-receptor type 1, 2-{4-[2-ACETYLAMINO-3-(4-CARBOXYMETHOXY-3-HYDROXY-PHENYL)-PROPIONYLAMINO]-BUTOXY}-6-HYDROXY-BENZOIC ACID METHYL ESTER (3 entities in total)
機能のキーワードprotein tyrosine phosphatase 1b, ptp1b monoacid-based and cell permeable, hydrolase
由来する生物種Homo sapiens (human)
細胞内の位置Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side  P18031
ポリマー鎖数1
分子量合計37884.15
構造登録者
主引用文献
Xin, Z.,Liu, G.,Abad-Zapatero, C.,Pei, Z.,Szczepankiewick, B.G.,Li, X.,Zhang, T.,Hutchins, C.W.,Hajduk, P.J.,Ballaron, S.J.,Stashko, M.A.,Lubben, T.H.,Trevillyan, J.M.,Jirousek, M.R.
Identification of a Monoacid-Based, Cell Permeable, Selective Inhibitor of Protein Tyrosine Phosphatase 1B
BIOORG.MED.CHEM.LETT., 13:3947-3950, 2003
PubMed: 14592481 (主引用文献が同じPDBエントリー)
DOI: 10.1016/j.bmcl.2003.08.064
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.3 Å)
NMR情報
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構造検証レポート

ClashscoreRamachandran outliersSidechain outliers190.7%3.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード