1QXK

Monoacid-Based, Cell Permeable, Selective Inhibitors of Protein Tyrosine Phosphatase 1B

1QXK の概要

• エントリーDOI: 10.2210/pdb1qxk/pdb
• 関連するPDBエントリー: 1NL9 1NNY 1NO6 1NZ7 1ONY 1PHO
• 分子名称: Protein-tyrosine phosphatase, non-receptor type 1, 2-{4-[2-ACETYLAMINO-3-(4-CARBOXYMETHOXY-3-HYDROXY-PHENYL)-PROPIONYLAMINO]-BUTOXY}-6-HYDROXY-BENZOIC ACID METHYL ESTER (3 entities in total)
• 機能のキーワード: protein tyrosine phosphatase 1b, ptp1b monoacid-based and cell permeable, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37884.15

構造登録者

Xin, Z.,Liu, G.,Abad-Zapatero, C.,Pei, Z.,Szczepankiewick, B.G.,Li, X.,Zhang, T.,Hutchins, C.W.,Hajduk, P.J.,Ballaron, S.J.,Stashko, M.A.,Lubben, T.H.,Trevillyan, J.M.,Jirousek, M.R. (登録日: 2003-09-08, 公開日: 2003-10-28, 最終更新日: 2023-08-23)

• 主引用文献: Xin, Z.,Liu, G.,Abad-Zapatero, C.,Pei, Z.,Szczepankiewick, B.G.,Li, X.,Zhang, T.,Hutchins, C.W.,Hajduk, P.J.,Ballaron, S.J.,Stashko, M.A.,Lubben, T.H.,Trevillyan, J.M.,Jirousek, M.R.; Identification of a Monoacid-Based, Cell Permeable, Selective Inhibitor of Protein Tyrosine Phosphatase 1B; BIOORG.MED.CHEM.LETT., 13:3947-3950, 2003; PubMed: 14592481; DOI: 10.1016/j.bmcl.2003.08.064

実験手法

X-RAY DIFFRACTION (2.3 Å)