1Q1M

A Highly Efficient Approach to a Selective and Cell Active PTP1B inhibitors

Summary for 1Q1M

Entry DOI	10.2210/pdb1q1m/pdb
Related	1NL9 1NNY 1NO6 1NZ7 1ONY 1PHO
Descriptor	Protein-tyrosine phosphatase, non-receptor type 1, 5-{2-FLUORO-5-[3-(3-HYDROXY-2-METHOXYCARBONYL-PHENOXY)-PROPENYL]-PHENYL}-ISOXAZOLE-3-CARBOXYLIC ACID (3 entities in total)
Functional Keywords	protein tyrosine phosphatase 1b, ptp1b, inhibitors with isoxazole-salicylate pharmacophores, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
Total number of polymer chains	1
Total formula weight	37778.99
Authors	Liu, G.,Xin, Z.,Pei, Z.,Hajduk, P.J.,Abad-Zapatero, C.,Hutchins, C.W.,Zhao, H.,Lubben, T.H.,Ballaron, S.J.,Haasch, D.L.,Kaszubska, W.,Rondinone, C.M.,Trevillyan, J.M.,Jirousek, M.R. (deposition date: 2003-07-22, release date: 2003-09-16, Last modification date: 2023-08-16)
Primary citation	Liu, G.,Xin, Z.,Pei, Z.,Hajduk, P.J.,Abad-Zapatero, C.,Hutchins, C.W.,Zhao, H.,Lubben, T.H.,Ballaron, S.J.,Haasch, D.L.,Kaszubska, W.,Rondinone, C.M.,Trevillyan, J.M.,Jirousek, M.R. Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor. J.Med.Chem., 46:4232-4235, 2003 Cited by PubMed: 13678400 DOI: 10.1021/jm034122o PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation