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1PRO

HIV-1 PROTEASE DIMER COMPLEXED WITH A-98881

Summary for 1PRO
Entry DOI10.2210/pdb1pro/pdb
DescriptorHIV-1 PROTEASE, (5R,6R)-2,4-BIS-(4-HYDROXY-3-METHOXYBENZYL)-1,5-DIBENZYL-3-OXO-6-HYDROXY-1,2,4-TRIAZACYCLOHEPTANE (3 entities in total)
Functional Keywordsaids, polyprotein, hydrolase, aspartic protease, endonuclease, rna-directed dna polymerase, hydrolase (aspartic protease)
Biological sourceHuman immunodeficiency virus 1
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P12499
Total number of polymer chains2
Total formula weight22245.24
Authors
Park, C.H.,Kong, X.P.,Dealwis, C.G. (deposition date: 1995-07-18, release date: 1996-08-17, Last modification date: 2024-02-14)
Primary citationSham, H.L.,Zhao, C.,Stewart, K.D.,Betebenner, D.A.,Lin, S.,Park, C.H.,Kong, X.P.,Rosenbrook Jr., W.,Herrin, T.,Madigan, D.,Vasavanonda, S.,Lyons, N.,Molla, A.,Saldivar, A.,Marsh, K.C.,McDonald, E.,Wideburg, N.E.,Denissen, J.F.,Robins, T.,Kempf, D.J.,Plattner, J.J.,Norbeck, D.W.
A novel, picomolar inhibitor of human immunodeficiency virus type 1 protease.
J.Med.Chem., 39:392-397, 1996
Cited by
PubMed: 8558507
DOI: 10.1021/jm9507183
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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