1PQ2

Crystal Structure of Human Drug Metabolizing Cytochrome P450 2C8

Summary for 1PQ2

• Entry DOI: 10.2210/pdb1pq2/pdb
• Related: 1DT6 1N6B
• Descriptor: Cytochrome P450 2C8, PHOSPHATE ION, PROTOPORPHYRIN IX CONTAINING FE, ... (5 entities in total)
• Functional Keywords: cytochrome p450, cyp2c8, membrane protein, taxol 6-hydroxylase, oxidoreductase
• Biological source: Homo sapiens (human)
• Cellular location: Endoplasmic reticulum membrane; Peripheral membrane protein: P10632
• Total number of polymer chains: 2
• Total formula weight: 109949.11

Authors

Schoch, G.A.,Yano, J.K.,Wester, M.R.,Griffin, K.J.,Stout, C.D.,Johnson, E.F. (deposition date: 2003-06-17, release date: 2004-01-13, Last modification date: 2023-08-16)

• Primary citation: Schoch, G.A.,Yano, J.K.,Wester, M.R.,Griffin, K.J.,Stout, C.D.,Johnson, E.F.; Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site; J.Biol.Chem., 279:9497-9503, 2004; PubMed: 14676196; DOI: 10.1074/jbc.M312516200

Experimental method

X-RAY DIFFRACTION (2.7 Å)