1PO1

POLIOVIRUS (TYPE 1, MAHONEY) IN COMPLEX WITH R80633, AN INHIBITOR OF VIRAL REPLICATION

Summary for 1PO1

• Entry DOI: 10.2210/pdb1po1/pdb
• Descriptor: POLIOVIRUS TYPE 1 MAHONEY, (METHYLPYRIDAZINE PIPERIDINE BUTYLOXYPHENYL)ETHYLACETATE, MYRISTIC ACID, ... (7 entities in total)
• Functional Keywords: poliovirus, picornavirus coat protein, anti-viral drugs, hydrolase, thiol protease, icosahedral virus, virus
• Biological source: Human poliovirus 1; More
• Cellular location: Capsid protein VP0: Virion. Capsid protein VP4: Virion. Capsid protein VP2: Virion. Capsid protein VP3: Virion. Capsid protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 2C: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3A: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3AB: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Viral protein genome-linked: Virion. Protease 3C: Host cytoplasm. Protein 3CD: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . RNA-directed RNA polymerase: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side : P03300 P03300 P03300
• Total number of polymer chains: 5
• Total formula weight: 98568.21

Authors

Hiremath, C.N.,Filman, D.J.,Grant, R.A.,Hogle, J.M. (deposition date: 1997-01-08, release date: 1997-12-03, Last modification date: 2023-08-09)

• Primary citation: Hiremath, C.N.,Filman, D.J.,Grant, R.A.,Hogle, J.M.; Ligand-induced conformational changes in poliovirus-antiviral drug complexes.; Acta Crystallogr.,Sect.D, 53:558-570, 1997; PubMed: 15299887; DOI: 10.1107/S0907444997000954

Experimental method

X-RAY DIFFRACTION (2.9 Å)