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1OPL

Structural basis for the auto-inhibition of c-Abl tyrosine kinase

Summary for 1OPL
Entry DOI10.2210/pdb1opl/pdb
Related1OPJ 1OPK
Descriptorproto-oncogene tyrosine-protein kinase, MYRISTIC ACID, 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE (3 entities in total)
Functional Keywordstransferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor: P00519
Total number of polymer chains2
Total formula weight123122.28
Authors
Nagar, B.,Hantschel, O.,Young, M.A.,Scheffzek, K.,Veach, D.,Bornmann, W.,Clarkson, B.,Superti-Furga, G.,Kuriyan, J. (deposition date: 2003-03-06, release date: 2003-04-08, Last modification date: 2023-08-16)
Primary citationNagar, B.,Hantschel, O.,Young, M.A.,Scheffzek, K.,Veach, D.,Bornmann, W.,Clarkson, B.,Superti-Furga, G.,Kuriyan, J.
Structural basis for the autoinhibition of c-Abl tyrosine kinase
Cell(Cambridge,Mass.), 112:859-871, 2003
Cited by
PubMed: 12654251
DOI: 10.1016/S0092-8674(03)00194-6
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.42 Å)
Structure validation

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