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1ONY

Oxalyl-Aryl-Amino Benzoic Acid inhibitors of PTP1B, compound 17

Summary for 1ONY
Entry DOI10.2210/pdb1ony/pdb
Related1NL9 1NNY 1NZ7 1No6 1onz
DescriptorProtein-tyrosine phosphatase, non-receptor type 1, 2-{[2-(2-CARBAMOYL-VINYL)-4-(2-METHANESULFONYLAMINO-2-PENTYLCARBAMOYL-ETHYL)-PHENYL]-OXALYL-AMINO}-BENZOIC ACID (3 entities in total)
Functional Keywordsprotein tyrosine phosphatase, oxalyl-aryl-amino benzoic acid inhibitor, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationEndoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
Total number of polymer chains1
Total formula weight37954.27
Authors
Primary citationLiu, G.,Szczepankiewicz, B.G.,Pei, Z.,Janowich, D.A.,Xin, Z.,Hadjuk, P.J.,Abad-Zapatero, C.,Liang, H.,Hutchins, C.W.,Fesik, S.W.,Ballaron, S.J.,Stashko, M.A.,Lubben, T.,Mika, A.K.,Zinker, B.A.,Trevillyan, J.M.,Jirousek, M.R.
Discovery and Structure-Activity Relationship of Oxalylarylaminobenzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B
J.Med.Chem., 46:2093-2103, 2003
Cited by
PubMed: 12747781
DOI: 10.1021/jm0205696
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.15 Å)
Structure validation

217705

數據於2024-03-27公開中

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