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1OKY

Structure of human PDK1 kinase domain in complex with staurosporine

Summary for 1OKY
Entry DOI10.2210/pdb1oky/pdb
Related1H1W 1OKZ 1UU3 1UU7 1UU8 1UU9 1UVR
Descriptor3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1, GLYCEROL, SULFATE ION, ... (5 entities in total)
Functional Keywordsprotein kinase, pkb, pdk1, staurosporine, transferase
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total formula weight36721.82
Authors
Komander, D.,Kular, G.S.,Alessi, D.R.,Van Aalten, D.M.F. (deposition date: 2003-08-01, release date: 2004-07-29, Last modification date: 2023-12-13)
Primary citationKomander, D.,Kular, G.S.,Bain, J.,Elliot, M.,Alessi, D.R.,Van Aalten, D.M.F.
Structural Basis for Ucn-01 (7-Hydroxystaurosporine) Specificity and Pdk1 (3-Phosphoinositide-Dependent Protein Kinase-1) Inhibition
Biochem.J., 375:255-, 2003
Cited by
PubMed: 12892559
DOI: 10.1042/BJ20031119
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

217705

数据于2024-03-27公开中

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