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1OKV

Cyclin A binding groove inhibitor H-Arg-Arg-Leu-Ile-Phe-NH2

Summary for 1OKV
Entry DOI10.2210/pdb1okv/pdb
Related1AQ1 1B38 1B39 1BUH 1CKP 1DI8 1DM2 1E1V 1E1X 1E9H 1F5Q 1FIN 1FQ1 1FVT 1FVV 1G5S 1GIH 1GII 1GIJ 1GY3 1GZ8 1H00 1H01 1H06 1H07 1H08 1H0U 1H0V 1H0W 1H1P 1H1Q 1H1R 1H1S 1H24 1H25 1H26 1H27 1H28 1HCK 1HCL 1JST 1JSU 1JSV 1JVP 1KE5 1KE6 1KE7 1KE8 1KE9 1OGU 1OI9 1OIQ 1OIR 1OIT 1OIU 1OIY 1OKU 1OKW 1OL1 1OL2 1P2A 1P5E 1PKD 1QMZ
DescriptorCELL DIVISION PROTEIN KINASE 2, CYCLIN A2, H-ARG-ARG-LEU-ILE-PHE-NH2, ... (4 entities in total)
Functional Keywordskinase-cyclin complex, cyclin a, inhibitor, ligand exchange, drug design, peptidomimetics, cell cycle, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHOMO SAPIENS (HUMAN)
More
Cellular locationCytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941
Nucleus : P20248
Total number of polymer chains6
Total formula weight129095.80
Authors
Kontopidis, G.,Andrews, M.,McInnes, C.,Cowan, A.,Powers, H.,Innes, L.,Plater, A.,Griffiths, G.,Paterson, D.,Zheleva, D.,Lane, D.,Green, S.,Walkinshaw, M.,Fischer, P. (deposition date: 2003-07-30, release date: 2003-12-11, Last modification date: 2023-12-13)
Primary citationKontopidis, G.,Andrews, M.,Mcinnes, C.,Cowan, A.,Powers, H.,Innes, L.,Plater, A.,Griffiths, G.,Paterson, D.,Zheleva, D.,Lane, D.,Green, S.,Walkinshaw, M.,Fischer, P.
Insights Into Cyclin Groove Recognition. Complex Crystal Structures and Inhibitor Design Through Ligand Exchange
Structure, 11:1537-, 2003
Cited by
PubMed: 14656438
DOI: 10.1016/J.STR.2003.11.006
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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건을2024-03-13부터공개중

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