1O5M

Structure of FPT bound to the inhibitor SCH66336

Summary for 1O5M

• Entry DOI: 10.2210/pdb1o5m/pdb
• Related: 1QBQ
• Descriptor: Protein farnesyltransferase alpha subunit, Protein farnesyltransferase beta subunit, ZINC ION, ... (6 entities in total)
• Functional Keywords: protein inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Rattus norvegicus (Norway rat); More
• Total number of polymer chains: 2
• Total formula weight: 93894.93

Authors

Strickland, C.L.,Weber, P.C.,Ganguly, A.K. (deposition date: 2003-09-26, release date: 2003-10-21, Last modification date: 2023-12-27)

• Primary citation: Strickland, C.L.,Weber, P.C.,Windsor, W.T.,Wu, Z.,Le, H.V.,Albanese, M.M.,Alvarez, C.S.,Cesarz, D.,del Rosario, J.,Deskus, J.,Mallams, A.K.,Njoroge, F.G.,Piwinski, J.J.,Remiszewski, S.,Rossman, R.R.,Taveras, A.G.,Vibulbhan, B.,Doll, R.J.,Girijavallabhan, V.M.,Ganguly, A.K.; Tricyclic Farnesyl Protein Transferase Inhibitors: Crystallographic and Calorimetric Studies of Structure-Activity Relationships; J.Med.Chem., 42:2125-2135, 1999; PubMed: 10377218; DOI: 10.1021/jm990030g

Experimental method

X-RAY DIFFRACTION (2.3 Å)