1NSG
THE STRUCTURE OF THE IMMUNOPHILIN-IMMUNOSUPPRESSANT FKBP12-RAPAMYCIN COMPLEX INTERACTING WITH HUMAN FRAP
Summary for 1NSG
| Entry DOI | 10.2210/pdb1nsg/pdb |
| Descriptor | FK506-BINDING PROTEIN, FKBP-RAPAMYCIN ASSOCIATED PROTEIN (FRAP), C49-METHYL RAPAMYCIN, ... (4 entities in total) |
| Functional Keywords | complex (isomerase-kinase), transferase, fkbp12, frap, rapamycin, complex (isomerase-kinase) complex, complex (isomerase/kinase) |
| Biological source | Homo sapiens (human) More |
| Cellular location | Cytoplasm: P62942 Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P42345 |
| Total number of polymer chains | 2 |
| Total formula weight | 24096.64 |
| Authors | Liang, J.,Choi, J.,Clardy, J. (deposition date: 1997-07-01, release date: 1998-03-18, Last modification date: 2024-02-14) |
| Primary citation | Liang, J.,Choi, J.,Clardy, J. Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution. Acta Crystallogr.,Sect.D, 55:736-744, 1999 Cited by PubMed: 10089303DOI: 10.1107/S0907444998014747 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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