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1NQL

Structure of the extracellular domain of human epidermal growth factor (EGF) receptor in an inactive (low pH) complex with EGF.

Summary for 1NQL
Entry DOI10.2210/pdb1nql/pdb
Descriptorepidermal growth factor receptor, epidermal growth factor, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywordscell surface receptor, tyrosine kinase, glycoprotein, endosomal, growth factor, auto-inhibition, hormone-growth factor receptor complex, hormone/growth factor receptor
Biological sourceHomo sapiens (human)
More
Total number of polymer chains2
Total formula weight78146.34
Authors
Ferguson, K.M.,Lemmon, M.A. (deposition date: 2003-01-21, release date: 2003-03-11, Last modification date: 2023-08-16)
Primary citationFerguson, K.M.,Berger, M.B.,Mendrola, J.M.,Cho, H.,Leahy, D.J.,Lemmon, M.A.
EGF activates its receptor by removing interactions that auto-inhibit ectodomain dimerization
Mol.Cell, 11:507-517, 2003
Cited by
PubMed: 12620237
DOI: 10.1016/S1097-2765(03)00047-9
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

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