1NKH

Crystal structure of Lactose synthase complex with UDP and Manganese

Replaces:  1J8X

Summary for 1NKH

Related1J92 1NHE 1J8W
DescriptorALPHA-LACTALBUMIN, BETA-1,4-GALACTOSYLTRANSFERASE, CALCIUM ION, ... (8 entities in total)
Functional Keywordslactose synthease, udp and mn binding, transferase activator-transferase complex, transferase activator/transferase
Biological sourceMus musculus (house mouse)
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Cellular locationSecreted P29752
Isoform Long: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Isoform Short: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Processed beta-1,4-galactosyltransferase 1: Secreted P08037
Total number of polymer chains4
Total molecular weight96704.84
Authors
Ramakrishnan, B.,Qasba, P.K. (deposition date: 2003-01-03, release date: 2003-01-14, Last modification date: 2011-07-13)
Primary citation
Ramakrishnan, B.,Qasba, P.K.
Crystal structure of lactose synthase reveals a large conformational change in its catalytic component, the beta-1,4-galactosyltransferase
J.Mol.Biol., 310:205-218, 2001
PubMed: 11419947 (PDB entries with the same primary citation)
DOI: 10.1006/jmbi.2001.4757
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.246180.3%4.4%4.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report