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1NI1

Imidazole and cyanophenyl farnesyl transferase inhibitors

Summary for 1NI1
Entry DOI10.2210/pdb1ni1/pdb
Related1N95 1N9A
DescriptorProtein farnesyltransferase alpha subunit, Protein farnesyltransferase beta subunit, ZINC ION, ... (5 entities in total)
Functional Keywordstransferase, prenyltransferase, ftase, cyanophenyl
Biological sourceRattus norvegicus (Norway rat)
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Total number of polymer chains2
Total formula weight83841.27
Authors
Tong, Y.,Lin, N.H.,Wang, L.,Hasvold, L.,Wang, W.,Leonard, N.,Li, T.,Li, Q.,Cohen, J.,Gu, W.Z.,Zhang, H.,Stoll, V.,Bauch, J.,Marsh, K.,Rosenberg, S.H.,Sham, H.L. (deposition date: 2002-12-20, release date: 2004-04-06, Last modification date: 2024-02-14)
Primary citationTong, Y.,Lin, N.H.,Wang, L.,Hasvold, L.,Wang, W.,Leonard, N.,Li, T.,Li, Q.,Cohen, J.,Gu, W.Z.,Zhang, H.,Stoll, V.,Bauch, J.,Marsh, K.,Rosenberg, S.H.,Sham, H.L.
Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability.
Bioorg.Med.Chem.Lett., 13:1571-1574, 2003
Cited by
PubMed: 12699757
DOI: 10.1016/S0960-894X(03)00195-1
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

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