1MF4

Structure-based design of potent and selective inhibitors of phospholipase A2: Crystal structure of the complex formed between phosholipase A2 from Naja Naja sagittifera and a designed peptide inhibitor at 1.9 A resolution

Summary for 1MF4

• Entry DOI: 10.2210/pdb1mf4/pdb
• Related: 1LFF 1LN8
• Descriptor: Phospholipase A2, VAL-ALA-PHE-ARG-SER, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: naja naja sagittifera, phospholipase a2, designed inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Naja sagittifera; More
• Cellular location: Secreted: P60045
• Total number of polymer chains: 2
• Total formula weight: 13748.26

Authors

Singh, R.K.,Vikram, P.,Paramsivam, M.,Jabeen, T.,Sharma, S.,Makker, J.,Dey, S.,Kaur, P.,Srinivasan, A.,Singh, T.P. (deposition date: 2002-08-09, release date: 2003-09-30, Last modification date: 2011-07-13)

• Primary citation: Singh, R.K.,Vikram, P.,Makker, J.,Jabeen, T.,Sharma, S.,Dey, S.,Kaur, P.,Srinivasan, A.,Singh, T.P.; Design of specific peptide inhibitors for group I phospholipase A2: structure of a complex formed between phospholipase A2 from Naja naja sagittifera (group I) and a designed peptide inhibitor Val-Ala-Phe-Arg-Ser (VAFRS) at 1.9 A resolution reveals unique features; Biochemistry, 42:11701-11706, 2003; PubMed: 14529280; DOI: 10.1021/bi035076x

Experimental method

X-RAY DIFFRACTION (1.9 Å)