1M6F

Strong Binding in the DNA Minor Groove by an Aromatic Diamidine With a Shape That Does Not Match the Curvature of the Groove

Summary for 1M6F

• Entry DOI: 10.2210/pdb1m6f/pdb
• Descriptor: DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'), MAGNESIUM ION, 3-[C-[N'-(3-CARBAMIMIDOYL-BENZYLIDENIUM)-HYDRAZINO]-[[AMINOMETHYLIDENE]AMINIUM]-IMINOMETHYL]-BENZAMIDINIUM, ... (4 entities in total)
• Functional Keywords: nucleic acids, minor groove binder, double helix, dna-drug complex, dna
• Total number of polymer chains: 2
• Total formula weight: 7703.51

Authors

Nguyen, B.,Lee, M.P.H.,Hamelberg, D.,Joubert, A.,Bailly, C.,Brun, R.,Neidle, S.,Wilson, W.D. (deposition date: 2002-07-16, release date: 2002-11-15, Last modification date: 2024-04-03)

• Primary citation: Nguyen, B.,Lee, M.P.H.,Hamelberg, D.,Joubert, A.,Bailly, C.,Brun, R.,Neidle, S.,Wilson, W.D.; Strong Binding in the DNA Minor Groove by an Aromatic Diamidine With a Shape That Does Not Match the Curvature of the Groove; J.Am.Chem.Soc., 124:13680-13681, 2002; PubMed: 12431090; DOI: 10.1021/ja027953c

Experimental method

X-RAY DIFFRACTION (1.78 Å)