1M63

Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes

Summary for 1M63

• Entry DOI: 10.2210/pdb1m63/pdb
• Related: 1BCK 1C5F 1CSA 1CWA 1CWB 1CWC 1CWF 1CWH 1CWI 1CWJ 1CWK 1CWL 1CWM 1CWO 1CYA 1CYB 1CYN 1IKF 1MF8 1MIK 1QNG 1QNH 1XQ7 2ESL 2OJU 2POY 2RMA 2RMB 2RMC 2WFJ 2X2C 2X7K 2Z6W 3BO7 3CYS 3EOV
• Related PRD ID: PRD_000142
• Descriptor: SERINE/THREONINE PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT, ALPHA ISOFORM, CALCINEURIN B SUBUNIT ISOFORM 1, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, ... (7 entities in total)
• Functional Keywords: hydrolase-isomerase-immunosuppressant complex, immunophilin, calcineurin, cyclosporin a, immunosuppressant, cyclophilin, hydrolase/isomerase/immunosuppressant
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Cell membrane : Q08209; Cytoplasm, cytosol : P63098; Cytoplasm : P62937
• Total number of polymer chains: 8
• Total formula weight: 163213.10

Authors

Huai, Q.,Kim, H.-Y.,Liu, Y.,Zhao, Y.,Mondragon, A.,Liu, J.O.,Ke, H. (deposition date: 2002-07-12, release date: 2002-09-25, Last modification date: 2024-04-03)

• Primary citation: Huai, Q.,Kim, H.-Y.,Liu, Y.,Zhao, Y.,Mondragon, A.,Liu, J.O.,Ke, H.; Crystal Structure of Calcineurin-Cyclophilin-Cyclosporin Shows Common But Distinct Recognition of Immunophilin-Drug Complexes; Proc.Natl.Acad.Sci.USA, 99:12037-, 2002; PubMed: 12218175; DOI: 10.1073/PNAS.192206699

Experimental method

X-RAY DIFFRACTION (2.8 Å)