1LPQ

Human DNA Topoisomerase I (70 Kda) In Non-Covalent Complex With A 22 Base Pair DNA Duplex Containing an 8-oxoG Lesion

Summary for 1LPQ

Related1A31 1A35 1A36 1EJ9
Descriptor5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*(8OG)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', DNA topoisomerase I, ... (4 entities in total)
Functional Keywordsprotein-dna complex, dna damage, induced conformational change, isomerase-dna complex, isomerase/dna
Biological sourceHomo sapiens (human)
Cellular locationNucleus, nucleolus P11387
Total number of polymer chains3
Total molecular weight80279.89
Authors
Lesher, D.T.,Pommier, Y.,Stewart, L.,Redinbo, M.R. (deposition date: 2002-05-08, release date: 2002-08-16, Last modification date: 2011-07-13)
Primary citation
Lesher, D.T.,Pommier, Y.,Stewart, L.,Redinbo, M.R.
8-Oxoguanine rearranges the active site of human topoisomerase I
Proc.Natl.Acad.Sci.USA, 99:12102-12107, 2002
PubMed: 12209008 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.192282699
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.14 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers445.6%8.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report