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1L8G

Crystal structure of PTP1B complexed with 7-(1,1-Dioxo-1H-benzo[d]isothiazol-3-yloxymethyl)-2-(oxalyl-amino)-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid

Summary for 1L8G
Entry DOI10.2210/pdb1l8g/pdb
Related1c83
DescriptorPROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1, 7-(1,1-DIOXO-1H-BENZO[D]ISOTHIAZOL-3-YLOXYMETHYL)-2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID (3 entities in total)
Functional Keywordsprotein-inhibitor, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationEndoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
Total number of polymer chains1
Total formula weight37832.08
Authors
Iversen, L.F.,Andersen, H.S.,Moller, K.B.,Olsen, O.H.,Peters, G.H.,Branner, S.,Mortensen, S.B.,Hansen, T.K.,Lau, J.,Ge, Y.,Holsworth, D.D.,Newman, M.J.,Moller, N.P.H. (deposition date: 2002-03-20, release date: 2002-05-08, Last modification date: 2024-02-14)
Primary citationIversen, L.F.,Andersen, H.S.,Moller, K.B.,Olsen, O.H.,Peters, G.H.,Branner, S.,Mortensen, S.B.,Hansen, T.K.,Lau, J.,Ge, Y.,Holsworth, D.D.,Newman, M.J.,Hundahl Moller, N.P.
Steric hindrance as a basis for structure-based design of selective inhibitors of protein-tyrosine phosphatases.
Biochemistry, 40:14812-14820, 2001
Cited by
PubMed: 11732900
DOI: 10.1021/bi011389l
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

217705

數據於2024-03-27公開中

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