1KNU

LIGAND BINDING DOMAIN OF THE HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA IN COMPLEX WITH A SYNTHETIC AGONIST

Summary for 1KNU

Entry DOI	10.2210/pdb1knu/pdb
Related	1PRG 2PRG
Descriptor	PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA, (S)-3-(4-(2-CARBAZOL-9-YL-ETHOXY)-PHENYL)-2-ETHOXY-PROPIONIC ACID (3 entities in total)
Functional Keywords	ppar, nuclear receptor, transcription, gene regulation, agonist complex, dna binding protein
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P37231
Total number of polymer chains	2
Total formula weight	63046.26
Authors	Svensson, L.A.,Mortensen, S.B.,Fleckner, J.,Woeldike, H.F. (deposition date: 2001-12-19, release date: 2002-12-19, Last modification date: 2023-10-25)
Primary citation	Sauerberg, P.,Pettersson, I.,Jeppesen, L.,Bury, P.S.,Mogensen, J.P.,Wassermann, K.,Brand, C.L.,Sturis, J.,Woldike, H.F.,Fleckner, J.,Andersen, A.-S.T.,Mortensen, S.B.,Svensson, L.A.,Rasmussen, H.B.,Lehmann, S.V.,Polivka, Z.,Sindelar, K.,Panajotova, V.,Ynddal, L.,Wulff, E.M. Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity J.MED.CHEM., 45:789-804, 2002 Cited by PubMed: 11831892 DOI: 10.1021/jm010964g PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation